Tom Xian-Xiu Chen 陳賢修 

Academic Appointments

  • Research Student - National Health Research Institutes, Lab of Ing-Kang Ho Distinguished Investigator and Vice President (2010.01 - 2011.12)



  • Master Program for Technology Law, China Medical University
    中國醫藥大學 科技法律研究所 學生
  • Doctor of Public Health / Preventive Medicine Field, Department of Public Health, China Medical University
    中國醫藥大學 公共衛生學系博士班 預防醫學組 畢業

  • Master of Public Health / Epidemiology Field, Institute of Environmental Health Sciences, China Medical University
    中國醫藥大學 環境醫學研究所 流行病學組 畢業


Professional Experiences

  • Reviewer - European Heart Journal, Medicine (2017-)

  • Freelancer:clinical trial protocol, medical research article, big data analysis (2017-)

  • Regulation of Clinical Trials Trials, Study Design and Statistical Analysis, Good Clinical Practice Lecturer – China medical university and National Taiwan University (2017-)

  • Clinical Trial Coordinator / Clinical Researcher - Department of NeuroSurgery, China Medical University Hospital (2011-)


Research Interests

Epidemiology, Big Data Analysis, Clinical Trial regulation, Health Law, Cerebrovascular Disease, Brain Disease, Brain Tumor



  • Unmet supportive care needs of survival patients with breast cancer in different cancer stages and treatment phases. Chou YH, Chia-Rong Hsieh V, Chen X, Huang TY, Shieh SH. Taiwan J Obstet Gynecol. 2020 Mar;59(2):231-236. doi: 10.1016/j.tjog.2020.01.010. PMID: 32127143 IF:1.2, Q4
  • Long-Term Follow-up in Patients with Spontaneous Intracerebral Hemorrhage Treated With or Without Surgical Intervention: a Large-Scale Retrospective Study. Chen X, Su YC, Chen CC, Guo JH, Wu CY, Wei ST, Chen DC, Lin JJ, Shieh SH, Chiu CD. Neurotherapeutics. 2019 Feb 20. doi: 10.1007/s13311-019-00722-7. 2019 Jul;16(3):891-900. doi: 10.1007/s13311-019-00722-7. PMID: 30788666 IF:5.552, Q1

  • Therapeutic mechanism of combined oral chelation therapy to maximize efficacy of iron removal in transfusion-dependent thalassemia major - a pilot study.Lin CH, Chen X, Wu CC, Wu KH, Song TS, Weng TF, Hsieh YW, Peng CT. Expert Rev Hematol. 2019 Apr;12(4):265-272. doi: 10.1080/17474086.2019.1593823. Epub 2019 Mar 28. PMID: 30920854 IF:2.505, Q3

  • Risk of subsequent stroke, with or without extracranial-intracranial bypass surgery: a nationwide, retrospective, population-based study. Chen X, Lin CL, Su YC, Chen KF, Lai SW, Wei ST, Peng CT, Chiu CD, Shieh SH, Chen CC. J Neurosurg. 2018 May 1:1-8. doi: 10.3171/2017.12.JNS172178. [Epub ahead of print] PMID: 29999468 IF:4.319, Q1

  • Inhibition of astrocytic activity alleviates sequela in acute stages of intracerebral hemorrhage.Chiu CD, Yao NW, Guo JH, Shen CC, Lee HT, Chiu YP, Ji HR, Chen X, Chen CC, Chang C.Oncotarget. 2017 Oct 24;8(55):94850-94861. doi: 10.18632/oncotarget.22022. eCollection 2017 Nov 7. PMID: 29212271 IF:5.168, Q1

  • PG2 for patients with acute spontaneous intracerebral hemorrhage: a double-blind, randomized, placebo-controlled study. Chen CC, Chen X, Li TC, Lin HL, Chu YT, Lee HC, Cheng YK, Chen DC, Tsai SC, Cho DY, Hsieh CL. Sci Rep. 2017 Mar 31;7:45628. doi: 10.1038/srep45628. PMID: 28361971 IF:4.259, Q1

  • Activation of N-methyl-D-aspartate receptor glycine site temporally ameliorates neuropsychiatric symptoms of Parkinson's disease with dementia. Tsai CH, Huang HC, Liu BL, Li CI, Lu MK, Chen X, Tsai MC, Yang YW, Lane HY. Psychiatry Clin Neurosci. 2014 Sep;68(9):692-700. doi: 10.1111/pcn.12175. Epub 2014 Apr 14. PMID: 24612097

  • Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients: double-blind, placebo-controlled, randomized study. Chen CC, Wei ST, Tsaia SC, Chen XX, Cho DY. Br J Neurosurg. 2013 Dec;27(6):803-7. doi: 10.3109/02688697.2013.793287. Epub 2013 May 8. PMID: 23656173

  • Wiskott-Aldrich syndrome with IgA nephropathy: a case report and literature review. Liu CH, Wu KH, Lin TY, Wei CC, Lin CY, Chen XX, Lee WI. Int Urol Nephrol. 2013 Oct;45(5):1495-500. doi: 10.1007/s11255-012-0178-0. Epub 2012 May 1. Review. PMID: 22547134

  • Metoclopramide improves the quality of tramadol PCA indistinguishable to morphine PCA: a prospective, randomized, double blind clinical comparison. Pang W, Liu YC, Maboudou E, Chen TX, Chois JM, Liao CC, Wu RS. Pain Med. 2013 Sep;14(9):1426-34. doi: 10.1111/pme.12166. Epub 2013 Jun 21. PMID: 23789747

  • Toll-like receptor 9 SNPs are susceptible to the development and progression of membranous glomerulonephritis: 27 years follow-up in Taiwan. Chen YT, Wei CC, Ng KL, Chen CH, Chan CJ, Chen XX, Chang YY, Chen SY, Tsai FJ. Ren Fail. 2013;35(10):1370-5. doi:10.3109/0886022X.2013.828264. Epub 2013 Aug 21. PMID: 23964786

  • The Risk Of Liver Cancer In Patients With Hepatitis Treated With Colchicine / Investigator Initiated Studies (IIS) 
  • A Pilot Study Of Ar121 In Chronic Hepatitis B Patients Protocol Number: Hbv-Cure-Ar121-01 / Arjil Pharmaceuticals Co., Ltd 
  • High-Density Lipoprotein Carries Proteomes Predict Large Vessel Occlusion Ischemic Stroke Patients Functional Outcome / Investigator Initiated Studies (IIS)
  • Large-Scale Intracranial Aneurysms Epidemiology Study: A 10-Year Clinical Survey / Investigator Initiated Studies (IIS) 
  • Organoid Culture Platform For Drug Response And Tolerance Test In Advance / Investigator Initiated Studies (IIS) 
  • Retrospective Study Of Multiple Brain Metastases Patients Treated With Surgical Resection Compared To Stereotactic Radiosurgery / Investigator Initiated Studies (IIS) 
  • A Pilot Study Of Electroacupuncture In Central Post Stroke Pain / Investigator Initiated Studies (IIS) 
  • A Phase II, Randomized, Open-Label, Parallel-Group Study To Evaluate The Efficacy And Safety Of Autologous Dendritic Cell Vaccination (ADCV01) As An Add-On Treatment For Primary Glioblastoma Multiforme (GBM) Patients / Ever Supreme Bio Technology & CMUH
  • STOP-MSU: Stopping Haemorrhage With Tranexamic Acid For Hyperacute Onset Presentation Including Mobile Stroke Units / Ministry Of Health And Welfare & The Florey Institute Of Neuroscience And Mental Health Melbourne Brain Centre, Austin Campus 
  • A Randomized, Double-Blind, Placebo-Controlled Trial Evaluating The Efficacy And Safety Of Yi-Gan San In Children And Adolescents With Tourette’s Disorder / Investigator Initiated Studies (IIS) 
  • A Pilot Study Of Tripod-Fix Vertebral Body Augmentation System In Vertebral Compression Fractures Caused By Osteoporosis / Wiltrom Medical 
  • A Pilot Study Of Prochlorperazine Maleate On Small Cell Lung Cancer Multiforme / Lumosa Therapeutics 
  • A Pilot Study Of Prochlorperazine Maleate On Glioblastoma Multiforme / Lumosa Therapeutics 
  • Efficacy Study Of Astragalus Membranaceus On Aneurysmal Subarachnoid Hemorrhage / Investigator Initiated Studies (IIS) 
  • Benefit Of Aspirin, Ticagrelor, Clopidogrel And Warfarin In The Secondary Prevention Of Ischemic Stroke / Investigator Initiated Studies (IIS) 
  • Risk Of Recurrent Stroke After Ischemic Stroke, With Or Without Extracranial-Intracranial Bypass Surgery / Investigator Initiated Studies (IIS) 
  • Astragalus Membranaceus Extraction For Acute Intracerebral Hemorrhage Stroke In Rat / Investigator Initiated Studies (IIS) 
  • Observational Follow-Up Study Of The Comparison In Traditional Pedicle Screw Insertion And Cortical Bone Screw Insertion / Investigator Initiated Studies (IIS) 
  • ABT-414 Alone Or ABT-414 Plus Temozolomide Versus Lomustine Or Temozolomide For Recurrent Glioblastoma: A Randomized Phase II Study Of The EORTC Brain Tumor Group / Abbvie Biopharmaceuticals 
  • STOP-AUST: The Spot Sign And Tranexamic Acid On Preventing ICH Growth – Australasia Trial / The Florey Institute Of Neuroscience And Mental Health Melbourne Brain Centre, Austin Campus 
  • Clinical Evaluation Of Cerebrolysin In Moderate TBI Patient / Investigator Initiated Studies (IIS) 
  • Navigation-Guided Endoscopic Surgery For Basal Ganglion Intracranial Hematoma Study / Investigator Initiated Studies (IIS) 
  • Development And Application Of A Genetic Test To Prevent Phenytoin-Induced Fatal Hypersensitivity Reactions / Investigator Initiated Studies (IIS) 
  • Symptomatic Intracranial Artery Occlusion EC-IC Bypass Study (SIOES) / Investigator Initiated Studies (IIS) 
  • Antihypertensive Treatment Of Acute Cerebral Hemorrhage (ATACH)-II / The National Institute Of Neurological Disorders And Stroke (NINDS) 
  • EXTEND (International): Extending The Time For Thrombolysis In Emergency Neurological Deficits (International) / National Stroke Research Institute (NSRI) Melbourne Brain Centre 
  • A Randomized, Double-Blind, Placebo-Controlled Trial To Investigate Safety And Efficacy Of Cerebrolysin In Patients With Traumatic Brain Injury / EVER Neuro Pharma Gmbh 
  • The Pilot Clinical Study Of PG2 Injection On Hemorrhagic Stroke / Phytohealth Corporation